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Lyclear Lotion 100ml
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Lyclear Lotion 100ml

Lyclear Lotion 100ml

$2.45

Original: $6.99

-65%
Lyclear Lotion 100ml

$6.99

$2.45

The Story

 

What Is Head Lice Treatment Lotion and How Does Lyclear Work?

 

Head lice are tiny parasitic insects that live on the scalp and feed on blood. They spread easily through direct head-to-head contact — particularly among school-age children — and can cause persistent itching and discomfort. If you or your child has been diagnosed with head lice, you are certainly not alone. The NHS estimates that head lice are extremely common in the UK, especially in children aged 4 to 11. Lyclear Lotion 100ml is a clinically established head lice treatment lotion containing permethrin 1% w/v, available over the counter without a prescription. You can browse our full range of treatments in our Head Lice collection if you want to compare options before deciding.

Lyclear Lotion is applied directly to the hair and scalp, working to eliminate live lice quickly and effectively. At just £6.99 for a 100ml bottle, it offers a straightforward, affordable solution for the whole family.

 

How Does Lyclear Lotion Kill Head Lice?

 

Permethrin, the active ingredient in Lyclear Lotion, belongs to a class of medicines called synthetic pyrethroids. It works by targeting the nervous system of head lice. Here is how the mechanism unfolds:

  • Permethrin binds to voltage-gated sodium channels in the nerve cell membranes of lice.
  • This binding keeps the channels open for longer than normal, causing prolonged nerve stimulation.
  • The result is paralysis of the louse, followed by death.
  • Because permethrin has limited ovicidal (egg-killing) activity, a second application after 7 days is recommended to kill any lice that hatch from surviving eggs.

This targeted mechanism means permethrin acts on the louse's nervous system without significant systemic absorption in humans when used as directed on the scalp.

 

Who Is Lyclear Lotion Suitable For?

 

Lyclear Lotion is suitable for most people who have a confirmed head lice infestation. It is important to confirm the presence of live lice before starting treatment — the NHS recommends using a fine-toothed detection comb on wet hair to check. This product is appropriate for:

  • Adults and children aged 6 months and over
  • People who prefer a lotion formulation over a spray or shampoo
  • Families looking for an OTC treatment without a GP visit
  • Those who have not responded to wet combing alone

It is not suitable for infants under 6 months without medical supervision, or for individuals with a known allergy to permethrin, chrysanthemums, or any other ingredient in the formulation.

 

How Does Lyclear Lotion Compare to Other Head Lice Treatments?

 

Feature Lyclear Lotion 100ml Dimeticone Lotion (e.g. Hedrin)
Active ingredient Permethrin 1% w/v Dimeticone 4% or 92%
Mechanism Neurotoxic — disrupts louse nervous system Physical — coats and suffocates lice
Resistance risk Some resistance reported in UK lice populations No resistance risk (physical action)
Age suitability 6 months and over Varies by product; some from 6 months
OTC availability Yes Yes

 

Is Lyclear Lotion Safe to Store at Home?

 

Lyclear Lotion should be stored below 25°C, away from direct heat and naked flames. The lotion is alcohol-based, which means it is flammable — keep it away from open fires, gas hobs, and cigarettes during and immediately after application. Store it out of the reach and sight of children. Do not use the lotion after the expiry date printed on the packaging. If you are also managing other skin conditions alongside a lice infestation, you may find our Skin Care collection helpful for complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Lotion 100ml specifications
Treatment category Head lice (pediculosis capitis)
Active ingredient Permethrin 1% w/v
Mechanism of action Synthetic pyrethroid — disrupts sodium channel function in louse nerve cells
Suitable for Adults and children aged 6 months and over
Pack size 100ml
Strength 1% w/v permethrin
UK classification Pharmacy (P) medicine
Drug class Synthetic pyrethroid insecticide
Preparation Topical lotion
Route of administration Topical (scalp and hair)

Specifications of Lyclear Lotion 100ml

 

What Is Lyclear Lotion and What Is It Used For?

 

Lyclear Lotion 100ml is a topical insecticidal lotion used to treat head lice infestations (pediculosis capitis) in adults and children aged 6 months and over. It contains permethrin 1% w/v as its active ingredient. Head lice are small, wingless insects that live close to the scalp, feeding on blood. They do not jump or fly — they spread through prolonged direct head-to-head contact. The NHS advises that anyone with a confirmed infestation should be treated promptly to prevent spread to others in the household.

 

What Do You Need to Know Before Using Lyclear Lotion?

 

Before applying Lyclear Lotion, read the following carefully. Do not use this product if any of the contraindications below apply to you.

Do not use Lyclear Lotion if you:

  • Are allergic to permethrin, chrysanthemums, or any other ingredient in the lotion
  • Have broken, infected, or severely inflamed skin on the scalp
  • Are treating an infant under 6 months of age without medical advice
  • Have a known sensitivity to pyrethroid or pyrethrin compounds

Use with caution if you:

  • Are pregnant or breastfeeding — seek pharmacist or GP advice first
  • Have asthma — the lotion contains alcohol, which may trigger bronchospasm in sensitive individuals
  • Have eczema or psoriasis on the scalp — the lotion may cause additional irritation

Known drug interactions:

  • No clinically significant interactions are known at topical doses
  • Avoid using other scalp treatments simultaneously unless advised by a pharmacist

 

How Should You Use Lyclear Lotion?

 

Always use Lyclear Lotion exactly as described in this leaflet or as directed by your pharmacist. The lotion is applied to dry hair — not wet hair — which is different from some other lice treatments. Follow these steps carefully:

  1. Ensure hair is completely dry before starting.
  2. Apply the lotion directly to the scalp, working it through the hair from roots to tips.
  3. Pay particular attention to the area behind the ears and at the nape of the neck, where lice tend to congregate.
  4. Leave the lotion on for 10 minutes.
  5. Rinse the hair thoroughly with warm water.
  6. Shampoo the hair as normal and rinse again.
  7. Use a fine-toothed nit comb to remove dead lice and eggs from the hair.
  8. Repeat the entire treatment after 7 days to kill any lice that have hatched since the first application.
Indication Age Group Dose Frequency
Head lice infestation Adults and children ≥ 6 months Sufficient lotion to cover all hair and scalp Two applications, 7 days apart
Head lice infestation Infants under 6 months Only under medical supervision As directed by a doctor

If you are also looking for products to support scalp health after treatment, our Hair Care collection includes a range of options that may help.

 

What Are the Possible Side Effects of Lyclear Lotion?

 

Like all medicines, Lyclear Lotion can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the scalp.

Common side effects (may affect up to 1 in 10 people):

  • Mild scalp itching or irritation
  • Temporary redness of the scalp
  • Mild burning or stinging sensation during or after application
  • Tingling of the scalp

Less common side effects (may affect up to 1 in 100 people):

  • Skin rash or hives at the application site
  • Swelling of the scalp or surrounding skin
  • Eye irritation if the lotion accidentally contacts the eyes

If you experience signs of a serious allergic reaction — such as difficulty breathing, swelling of the face or throat, or a widespread rash — stop using the lotion immediately and seek emergency medical attention. It is worth noting that some itching after treatment may simply be a reaction to dead lice and eggs rather than a side effect of the lotion itself.

 

How Should You Store Lyclear Lotion?

 

Correct storage helps maintain the safety and effectiveness of Lyclear Lotion. Follow these instructions:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and sources of heat
  • Keep away from naked flames — the lotion is flammable due to its alcohol content
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the bottle or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist

If you are managing other conditions alongside head lice — for example, a child who also has a skin condition — our Baby and Toddler collection includes a range of gentle, age-appropriate products worth exploring.

References

  1. https://www.nhs.uk/conditions/head-lice-and-nits/
  2. https://www.nhs.uk/conditions/head-lice-and-nits/treatment/
  3. https://www.nhs.uk/medicines/permethrin/
  4. https://www.nhs.uk/conditions/head-lice-and-nits/symptoms/
  5. https://bnf.nice.org.uk/drugs/permethrin/

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Lotion 100ml online in the UK?

You can buy Lyclear Lotion 100ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £6.99. It is available without a prescription as an over-the-counter medicine. Browse our full Head Lice collection for additional treatment options and accessories such as detection combs.

How does Lyclear Lotion work against head lice?

Lyclear Lotion contains permethrin 1% w/v, a synthetic pyrethroid that disrupts the voltage-gated sodium channels in the nerve cell membranes of head lice, causing paralysis and death. It acts on live lice within 10 minutes of application. Because permethrin has limited activity against eggs, a second treatment after 7 days is essential to kill any newly hatched lice.

How do I use Lyclear Lotion step by step?

Apply Lyclear Lotion to completely dry hair, working it from the roots through to the tips and paying close attention to the area behind the ears and the nape of the neck. Leave it on for 10 minutes, then rinse with warm water and shampoo as normal. Use a fine-toothed nit comb to remove dead lice and eggs, and repeat the full treatment after 7 days.

What is the correct dose of Lyclear Lotion?

There is no fixed volume dose — you should apply enough lotion to thoroughly cover all of the hair and scalp from roots to tips. For most adults and older children with longer hair, the full 100ml bottle may be needed for two treatments. Two applications, spaced 7 days apart, constitute a complete course of treatment.

Is Lyclear Lotion safe for children?

Yes, Lyclear Lotion is suitable for children aged 6 months and over when used as directed. Children under 6 months should only be treated under the supervision of a doctor or healthcare professional. Always keep the lotion away from the eyes, mouth, and nose during application, and rinse immediately with water if accidental contact occurs.

Can I use Lyclear Lotion if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your doctor or pharmacist before using Lyclear Lotion. Topical permethrin is considered to have minimal systemic absorption, but professional guidance is always recommended during pregnancy and lactation. Your pharmacist can help you weigh up the options and suggest the most appropriate treatment for your situation.

How long does Lyclear Lotion take to work?

Lyclear Lotion begins to kill live head lice within 10 minutes of application to the scalp and hair. You may notice dead lice when combing through the hair after rinsing. However, the full treatment course — two applications, 7 days apart — is required to ensure all lice, including those that hatch after the first treatment, are eliminated.

What are the side effects of Lyclear Lotion and how do I manage them?

The most common side effects are mild scalp irritation, temporary itching, redness, or a brief burning sensation at the application site — these usually resolve on their own within a short time. If you experience a more significant reaction such as a rash, swelling, or difficulty breathing, stop using the lotion immediately and seek medical advice. Bear in mind that some post-treatment itching is simply caused by the presence of dead lice and eggs rather than the lotion itself.

Who is eligible to use Lyclear Lotion?

Lyclear Lotion is suitable for adults and children aged 6 months and over who have a confirmed head lice infestation. It is not suitable for people with a known allergy to permethrin, chrysanthemums, or pyrethroid compounds, or for those with broken or severely inflamed skin on the scalp. People with asthma should use it with caution due to the alcohol content, and should seek pharmacist advice first.

What happens if I only do one treatment and skip the second application?

Skipping the second treatment significantly increases the risk of the infestation returning. Permethrin does not reliably kill all lice eggs, so any eggs that survive the first application will hatch within 7–10 days, restarting the infestation cycle. The NHS recommends completing both applications, 7 days apart, to achieve a successful outcome.

What are the alternatives to Lyclear Lotion for head lice?

Alternatives include dimeticone-based products such as Hedrin, which work by physically coating and suffocating lice rather than using an insecticide — making them useful where permethrin resistance is suspected. Wet combing with a fine-toothed detection comb every 4 days for at least 2 weeks is a non-chemical option recommended by the NHS. You can explore further options in our Head Lice collection.

Can head lice become resistant to Lyclear Lotion?

Yes, there is evidence that some head lice populations in the UK have developed resistance to permethrin over time, which can reduce the effectiveness of permethrin-based treatments. If you complete two full treatments with Lyclear Lotion and still find live lice, speak to your pharmacist about switching to a product with a different mechanism of action, such as a dimeticone-based lotion. Resistance does not mean the product is unsafe — it simply means an alternative may be more effective for your particular infestation.

How long should I continue treating head lice?

A standard course of Lyclear Lotion consists of two applications, 7 days apart. After completing both treatments, check the hair with a fine-toothed detection comb to confirm that no live lice remain. If live lice are still present after the second treatment, consult your pharmacist, as a different product may be needed. Routine re-treatment is not recommended unless a new infestation is confirmed.

Is there any research supporting the use of permethrin for head lice?

Permethrin has been used as a head lice treatment for several decades and is included in NHS treatment guidance for pediculosis capitis. Clinical studies have demonstrated its efficacy against live lice, though its ovicidal activity is limited, which is why a two-treatment protocol is standard practice. The NHS and BNF both list permethrin as an established treatment option for head lice in the UK.

Should I treat everyone in the household if one person has head lice?

The NHS recommends checking all household members and close contacts for head lice using a fine-toothed detection comb on wet hair. Only those in whom live lice are confirmed should be treated — treating people who do not have lice is not recommended and may contribute unnecessarily to resistance. If multiple family members are affected, it is practical to treat them all on the same day to prevent re-infestation between household members.

Description

 

What Is Head Lice Treatment Lotion and How Does Lyclear Work?

 

Head lice are tiny parasitic insects that live on the scalp and feed on blood. They spread easily through direct head-to-head contact — particularly among school-age children — and can cause persistent itching and discomfort. If you or your child has been diagnosed with head lice, you are certainly not alone. The NHS estimates that head lice are extremely common in the UK, especially in children aged 4 to 11. Lyclear Lotion 100ml is a clinically established head lice treatment lotion containing permethrin 1% w/v, available over the counter without a prescription. You can browse our full range of treatments in our Head Lice collection if you want to compare options before deciding.

Lyclear Lotion is applied directly to the hair and scalp, working to eliminate live lice quickly and effectively. At just £6.99 for a 100ml bottle, it offers a straightforward, affordable solution for the whole family.

 

How Does Lyclear Lotion Kill Head Lice?

 

Permethrin, the active ingredient in Lyclear Lotion, belongs to a class of medicines called synthetic pyrethroids. It works by targeting the nervous system of head lice. Here is how the mechanism unfolds:

  • Permethrin binds to voltage-gated sodium channels in the nerve cell membranes of lice.
  • This binding keeps the channels open for longer than normal, causing prolonged nerve stimulation.
  • The result is paralysis of the louse, followed by death.
  • Because permethrin has limited ovicidal (egg-killing) activity, a second application after 7 days is recommended to kill any lice that hatch from surviving eggs.

This targeted mechanism means permethrin acts on the louse's nervous system without significant systemic absorption in humans when used as directed on the scalp.

 

Who Is Lyclear Lotion Suitable For?

 

Lyclear Lotion is suitable for most people who have a confirmed head lice infestation. It is important to confirm the presence of live lice before starting treatment — the NHS recommends using a fine-toothed detection comb on wet hair to check. This product is appropriate for:

  • Adults and children aged 6 months and over
  • People who prefer a lotion formulation over a spray or shampoo
  • Families looking for an OTC treatment without a GP visit
  • Those who have not responded to wet combing alone

It is not suitable for infants under 6 months without medical supervision, or for individuals with a known allergy to permethrin, chrysanthemums, or any other ingredient in the formulation.

 

How Does Lyclear Lotion Compare to Other Head Lice Treatments?

 

Feature Lyclear Lotion 100ml Dimeticone Lotion (e.g. Hedrin)
Active ingredient Permethrin 1% w/v Dimeticone 4% or 92%
Mechanism Neurotoxic — disrupts louse nervous system Physical — coats and suffocates lice
Resistance risk Some resistance reported in UK lice populations No resistance risk (physical action)
Age suitability 6 months and over Varies by product; some from 6 months
OTC availability Yes Yes

 

Is Lyclear Lotion Safe to Store at Home?

 

Lyclear Lotion should be stored below 25°C, away from direct heat and naked flames. The lotion is alcohol-based, which means it is flammable — keep it away from open fires, gas hobs, and cigarettes during and immediately after application. Store it out of the reach and sight of children. Do not use the lotion after the expiry date printed on the packaging. If you are also managing other skin conditions alongside a lice infestation, you may find our Skin Care collection helpful for complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Lotion 100ml specifications
Treatment category Head lice (pediculosis capitis)
Active ingredient Permethrin 1% w/v
Mechanism of action Synthetic pyrethroid — disrupts sodium channel function in louse nerve cells
Suitable for Adults and children aged 6 months and over
Pack size 100ml
Strength 1% w/v permethrin
UK classification Pharmacy (P) medicine
Drug class Synthetic pyrethroid insecticide
Preparation Topical lotion
Route of administration Topical (scalp and hair)

Specifications of Lyclear Lotion 100ml

 

What Is Lyclear Lotion and What Is It Used For?

 

Lyclear Lotion 100ml is a topical insecticidal lotion used to treat head lice infestations (pediculosis capitis) in adults and children aged 6 months and over. It contains permethrin 1% w/v as its active ingredient. Head lice are small, wingless insects that live close to the scalp, feeding on blood. They do not jump or fly — they spread through prolonged direct head-to-head contact. The NHS advises that anyone with a confirmed infestation should be treated promptly to prevent spread to others in the household.

 

What Do You Need to Know Before Using Lyclear Lotion?

 

Before applying Lyclear Lotion, read the following carefully. Do not use this product if any of the contraindications below apply to you.

Do not use Lyclear Lotion if you:

  • Are allergic to permethrin, chrysanthemums, or any other ingredient in the lotion
  • Have broken, infected, or severely inflamed skin on the scalp
  • Are treating an infant under 6 months of age without medical advice
  • Have a known sensitivity to pyrethroid or pyrethrin compounds

Use with caution if you:

  • Are pregnant or breastfeeding — seek pharmacist or GP advice first
  • Have asthma — the lotion contains alcohol, which may trigger bronchospasm in sensitive individuals
  • Have eczema or psoriasis on the scalp — the lotion may cause additional irritation

Known drug interactions:

  • No clinically significant interactions are known at topical doses
  • Avoid using other scalp treatments simultaneously unless advised by a pharmacist

 

How Should You Use Lyclear Lotion?

 

Always use Lyclear Lotion exactly as described in this leaflet or as directed by your pharmacist. The lotion is applied to dry hair — not wet hair — which is different from some other lice treatments. Follow these steps carefully:

  1. Ensure hair is completely dry before starting.
  2. Apply the lotion directly to the scalp, working it through the hair from roots to tips.
  3. Pay particular attention to the area behind the ears and at the nape of the neck, where lice tend to congregate.
  4. Leave the lotion on for 10 minutes.
  5. Rinse the hair thoroughly with warm water.
  6. Shampoo the hair as normal and rinse again.
  7. Use a fine-toothed nit comb to remove dead lice and eggs from the hair.
  8. Repeat the entire treatment after 7 days to kill any lice that have hatched since the first application.
Indication Age Group Dose Frequency
Head lice infestation Adults and children ≥ 6 months Sufficient lotion to cover all hair and scalp Two applications, 7 days apart
Head lice infestation Infants under 6 months Only under medical supervision As directed by a doctor

If you are also looking for products to support scalp health after treatment, our Hair Care collection includes a range of options that may help.

 

What Are the Possible Side Effects of Lyclear Lotion?

 

Like all medicines, Lyclear Lotion can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the scalp.

Common side effects (may affect up to 1 in 10 people):

  • Mild scalp itching or irritation
  • Temporary redness of the scalp
  • Mild burning or stinging sensation during or after application
  • Tingling of the scalp

Less common side effects (may affect up to 1 in 100 people):

  • Skin rash or hives at the application site
  • Swelling of the scalp or surrounding skin
  • Eye irritation if the lotion accidentally contacts the eyes

If you experience signs of a serious allergic reaction — such as difficulty breathing, swelling of the face or throat, or a widespread rash — stop using the lotion immediately and seek emergency medical attention. It is worth noting that some itching after treatment may simply be a reaction to dead lice and eggs rather than a side effect of the lotion itself.

 

How Should You Store Lyclear Lotion?

 

Correct storage helps maintain the safety and effectiveness of Lyclear Lotion. Follow these instructions:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and sources of heat
  • Keep away from naked flames — the lotion is flammable due to its alcohol content
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the bottle or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist

If you are managing other conditions alongside head lice — for example, a child who also has a skin condition — our Baby and Toddler collection includes a range of gentle, age-appropriate products worth exploring.

References

  1. https://www.nhs.uk/conditions/head-lice-and-nits/
  2. https://www.nhs.uk/conditions/head-lice-and-nits/treatment/
  3. https://www.nhs.uk/medicines/permethrin/
  4. https://www.nhs.uk/conditions/head-lice-and-nits/symptoms/
  5. https://bnf.nice.org.uk/drugs/permethrin/

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Lotion 100ml online in the UK?

You can buy Lyclear Lotion 100ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £6.99. It is available without a prescription as an over-the-counter medicine. Browse our full Head Lice collection for additional treatment options and accessories such as detection combs.

How does Lyclear Lotion work against head lice?

Lyclear Lotion contains permethrin 1% w/v, a synthetic pyrethroid that disrupts the voltage-gated sodium channels in the nerve cell membranes of head lice, causing paralysis and death. It acts on live lice within 10 minutes of application. Because permethrin has limited activity against eggs, a second treatment after 7 days is essential to kill any newly hatched lice.

How do I use Lyclear Lotion step by step?

Apply Lyclear Lotion to completely dry hair, working it from the roots through to the tips and paying close attention to the area behind the ears and the nape of the neck. Leave it on for 10 minutes, then rinse with warm water and shampoo as normal. Use a fine-toothed nit comb to remove dead lice and eggs, and repeat the full treatment after 7 days.

What is the correct dose of Lyclear Lotion?

There is no fixed volume dose — you should apply enough lotion to thoroughly cover all of the hair and scalp from roots to tips. For most adults and older children with longer hair, the full 100ml bottle may be needed for two treatments. Two applications, spaced 7 days apart, constitute a complete course of treatment.

Is Lyclear Lotion safe for children?

Yes, Lyclear Lotion is suitable for children aged 6 months and over when used as directed. Children under 6 months should only be treated under the supervision of a doctor or healthcare professional. Always keep the lotion away from the eyes, mouth, and nose during application, and rinse immediately with water if accidental contact occurs.

Can I use Lyclear Lotion if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your doctor or pharmacist before using Lyclear Lotion. Topical permethrin is considered to have minimal systemic absorption, but professional guidance is always recommended during pregnancy and lactation. Your pharmacist can help you weigh up the options and suggest the most appropriate treatment for your situation.

How long does Lyclear Lotion take to work?

Lyclear Lotion begins to kill live head lice within 10 minutes of application to the scalp and hair. You may notice dead lice when combing through the hair after rinsing. However, the full treatment course — two applications, 7 days apart — is required to ensure all lice, including those that hatch after the first treatment, are eliminated.

What are the side effects of Lyclear Lotion and how do I manage them?

The most common side effects are mild scalp irritation, temporary itching, redness, or a brief burning sensation at the application site — these usually resolve on their own within a short time. If you experience a more significant reaction such as a rash, swelling, or difficulty breathing, stop using the lotion immediately and seek medical advice. Bear in mind that some post-treatment itching is simply caused by the presence of dead lice and eggs rather than the lotion itself.

Who is eligible to use Lyclear Lotion?

Lyclear Lotion is suitable for adults and children aged 6 months and over who have a confirmed head lice infestation. It is not suitable for people with a known allergy to permethrin, chrysanthemums, or pyrethroid compounds, or for those with broken or severely inflamed skin on the scalp. People with asthma should use it with caution due to the alcohol content, and should seek pharmacist advice first.

What happens if I only do one treatment and skip the second application?

Skipping the second treatment significantly increases the risk of the infestation returning. Permethrin does not reliably kill all lice eggs, so any eggs that survive the first application will hatch within 7–10 days, restarting the infestation cycle. The NHS recommends completing both applications, 7 days apart, to achieve a successful outcome.

What are the alternatives to Lyclear Lotion for head lice?

Alternatives include dimeticone-based products such as Hedrin, which work by physically coating and suffocating lice rather than using an insecticide — making them useful where permethrin resistance is suspected. Wet combing with a fine-toothed detection comb every 4 days for at least 2 weeks is a non-chemical option recommended by the NHS. You can explore further options in our Head Lice collection.

Can head lice become resistant to Lyclear Lotion?

Yes, there is evidence that some head lice populations in the UK have developed resistance to permethrin over time, which can reduce the effectiveness of permethrin-based treatments. If you complete two full treatments with Lyclear Lotion and still find live lice, speak to your pharmacist about switching to a product with a different mechanism of action, such as a dimeticone-based lotion. Resistance does not mean the product is unsafe — it simply means an alternative may be more effective for your particular infestation.

How long should I continue treating head lice?

A standard course of Lyclear Lotion consists of two applications, 7 days apart. After completing both treatments, check the hair with a fine-toothed detection comb to confirm that no live lice remain. If live lice are still present after the second treatment, consult your pharmacist, as a different product may be needed. Routine re-treatment is not recommended unless a new infestation is confirmed.

Is there any research supporting the use of permethrin for head lice?

Permethrin has been used as a head lice treatment for several decades and is included in NHS treatment guidance for pediculosis capitis. Clinical studies have demonstrated its efficacy against live lice, though its ovicidal activity is limited, which is why a two-treatment protocol is standard practice. The NHS and BNF both list permethrin as an established treatment option for head lice in the UK.

Should I treat everyone in the household if one person has head lice?

The NHS recommends checking all household members and close contacts for head lice using a fine-toothed detection comb on wet hair. Only those in whom live lice are confirmed should be treated — treating people who do not have lice is not recommended and may contribute unnecessarily to resistance. If multiple family members are affected, it is practical to treat them all on the same day to prevent re-infestation between household members.