Original: $5.19
-65%$5.19
$1.82The Story
What Are Ibuprofen 400mg Tablets Used For?
If you're dealing with a nagging headache, aching muscles, or the kind of back pain that makes it hard to get through the day, ibuprofen 400mg tablets are one of the most widely used over-the-counter options available in the UK. Ibuprofen Numark 24 x 400mg Tablets offer a reliable, clinically established way to manage mild to moderate pain, reduce inflammation, and bring down a high temperature — all in one convenient pack. At just £5.19 for 24 tablets, it's an accessible choice for everyday pain relief.
Ibuprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It's been used safely for decades and is recommended by the NHS for a wide range of common conditions. Whether you're browsing our pain relief collection for something to keep in the medicine cabinet or you need relief right now, this product is worth knowing about.
How Do Ibuprofen 400mg Tablets Work in the Body?
Ibuprofen works by inhibiting cyclo-oxygenase (COX) enzymes — specifically COX-1 and COX-2. These enzymes drive the production of prostaglandins, which are chemical messengers that trigger pain, swelling, and fever. By blocking them, ibuprofen reduces the inflammatory response at the source rather than simply masking discomfort.
- Inhibits COX-1 and COX-2 enzymes throughout the body
- Reduces prostaglandin synthesis, lowering pain signals
- Decreases local inflammation and swelling in affected tissues
- Acts on the hypothalamus to help normalise elevated body temperature
The onset of action is typically within 20 to 30 minutes of taking a dose orally, with peak plasma concentrations reached within one to two hours. This makes it a practical option when you need relief that works relatively quickly.
Who Is Suitable for Ibuprofen Numark 400mg Tablets?
These tablets are suitable for adults and young people aged 12 and over who need short-term relief from mild to moderate pain or fever. They're particularly useful for:
- Headaches and migraines
- Dental pain and toothache
- Muscular aches, back pain, and joint pain
- Period pain (dysmenorrhoea)
- Fever and symptoms associated with colds and flu
- Minor sports injuries and sprains
They are not suitable for children under 12, pregnant women (especially from 20 weeks onwards), or anyone with a known allergy to ibuprofen or other NSAIDs. If you have a history of stomach ulcers, kidney problems, or cardiovascular disease, speak to your pharmacist or GP before use.
How Do Ibuprofen 400mg Tablets Compare to Alternatives?
| Feature | Ibuprofen Numark 400mg | Paracetamol 500mg |
|---|---|---|
| Active ingredient | Ibuprofen (NSAID) | Paracetamol (analgesic/antipyretic) |
| Anti-inflammatory action | Yes | No |
| Suitable for stomach-sensitive patients | Take with food; caution advised | Generally better tolerated |
| Suitable from age | 12 years and over (400mg strength) | 2 months and over (age-appropriate dose) |
How Should You Store Ibuprofen Numark 400mg Tablets?
Store your ibuprofen 400mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original packaging and out of reach of children at all times. Do not use the tablets after the expiry date printed on the pack — if in doubt, return them to your local pharmacy for safe disposal.
If you're managing multiple health conditions and looking for complementary products, you might also find our vitamins and supplements collection useful for supporting overall wellbeing alongside your pain management routine.
This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.
Ibuprofen Numark 24 x 400mg Tablets specifications
| Treatment category | Pain relief, anti-inflammatory, antipyretic |
| Mechanism of action | COX-1 and COX-2 enzyme inhibition |
| Effective for | Mild to moderate pain, inflammation, fever |
| Suitable for | Adults and young people aged 12 and over |
| Active ingredient | Ibuprofen 400mg |
| Pack size | 24 tablets |
| Strength | 400mg |
| UK classification | Pharmacy (P) medicine |
| Drug class | Non-steroidal anti-inflammatory drug (NSAID) |
| Preparation | Film-coated tablet |
| Route of administration | Oral |
Specifications of Ibuprofen Numark 24 x 400mg Tablets
What Is Ibuprofen Numark 400mg and What Is It Used For?
Ibuprofen Numark 400mg Tablets contain ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain, reduce inflammation, and lower fever. It is indicated for adults and young people aged 12 and over. Common uses include headaches, dental pain, period pain, muscular aches, back pain, and the symptoms of colds and flu. The NHS lists ibuprofen as one of the standard first-line options for short-term pain management in adults.
What Do You Need to Know Before Using Ibuprofen Numark 400mg?
Before taking these tablets, it's important to check whether they are appropriate for you. Do not take ibuprofen if any of the following apply:
- You are allergic to ibuprofen, aspirin, or any other NSAID
- You have or have had a peptic ulcer or gastrointestinal bleeding
- You have severe heart failure, severe kidney disease, or severe liver disease
- You are in the third trimester of pregnancy (28 weeks or more)
- You are under 12 years of age
- You have been told to avoid NSAIDs by your doctor
Use with caution if you have asthma, high blood pressure, a history of heart disease, or mild to moderate kidney or liver impairment. Ibuprofen may interact with the following medicines — always tell your pharmacist what you are taking:
- Aspirin and other NSAIDs (increased risk of side effects)
- Warfarin and other anticoagulants (increased bleeding risk)
- Lithium (ibuprofen can raise lithium blood levels)
- Methotrexate (risk of toxicity increased)
- Antihypertensives including ACE inhibitors and diuretics (reduced effectiveness)
- SSRIs (increased risk of gastrointestinal bleeding)
How Should You Use Ibuprofen Numark 400mg Tablets?
Always take ibuprofen exactly as directed on the label or as advised by your pharmacist. Taking it with food or milk helps protect the stomach lining and reduces the risk of indigestion.
- Take one 400mg tablet with or after food
- Swallow the tablet whole with a full glass of water
- Wait at least four to six hours before taking another dose
- Do not take more than three tablets (1,200mg) in any 24-hour period
- Do not use for more than three days for fever or ten days for pain without medical advice
| Indication | Age Group | Dose | Frequency |
|---|---|---|---|
| Pain / Inflammation | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
| Fever | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
| Period pain | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
If you're also managing digestive discomfort alongside pain, you may find our indigestion collection helpful for supporting stomach comfort while taking NSAIDs.
What Are the Possible Side Effects of Ibuprofen Numark 400mg?
Like all medicines, ibuprofen can cause side effects, although not everyone experiences them. Knowing what to look out for helps you use this medicine safely.
Common side effects (may affect up to 1 in 10 people):
- Nausea and vomiting
- Indigestion and heartburn
- Stomach pain or discomfort
- Diarrhoea or constipation
- Headache
Less common side effects (may affect up to 1 in 100 people):
- Dizziness or drowsiness
- Fluid retention (oedema)
- Raised blood pressure
- Skin rash or itching
- Worsening of asthma symptoms
Seek immediate medical attention if you experience signs of a serious allergic reaction (swelling of the face, lips, or throat, difficulty breathing), black or bloody stools, or severe stomach pain. These may indicate a rare but serious reaction requiring urgent care. If you're also managing cold or flu symptoms alongside pain, our cold and flu collection has additional products that may help.
How Should You Store Ibuprofen Numark 400mg Tablets?
- Store below 25°C in a dry place away from direct heat and sunlight
- Keep in the original blister packaging until use
- Keep out of the sight and reach of children
- Do not use after the expiry date printed on the pack
- Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy
References
- https://www.nhs.uk/medicines/ibuprofen-for-adults/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/who-can-and-cannot-take-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/side-effects-of-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/how-and-when-to-take-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/taking-ibuprofen-with-other-medicines-and-herbal-supplements/
- https://bnf.nice.org.uk/drugs/ibuprofen/
Written and reviewed by our qualified team
Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.
Frequently Asked Questions
Where can I buy ibuprofen 400mg tablets online in the UK?
You can buy Ibuprofen Numark 24 x 400mg Tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply add the product to your basket and complete your order for convenient home delivery. Browse our full pain relief collection for more options.
How does ibuprofen 400mg work in the body?
Ibuprofen works by blocking COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins — the chemicals that cause pain, swelling, and fever. By reducing prostaglandin levels, ibuprofen tackles the underlying inflammatory process rather than just dulling the sensation of pain. This is why it's particularly effective for conditions involving inflammation, such as sprains or period pain.
How do I take ibuprofen 400mg tablets step by step?
Take one 400mg tablet with or after food, swallowed whole with a full glass of water. Wait at least four to six hours before taking another dose, and do not exceed three tablets in any 24-hour period. If your symptoms persist beyond three days (fever) or ten days (pain), consult your pharmacist or GP.
What is the correct dose of ibuprofen 400mg for adults?
The standard adult dose is one 400mg tablet taken up to three times daily, with at least four to six hours between each dose. The maximum daily dose for self-treatment is 1,200mg (three tablets) in 24 hours. Higher doses are sometimes prescribed by doctors but should not be taken without medical supervision.
When is the best time to take ibuprofen 400mg tablets?
There is no single "best" time of day — the most important thing is to take ibuprofen with or after food to protect your stomach lining. If you're taking it for period pain, starting at the first sign of discomfort (rather than waiting for pain to peak) tends to give better results. Space your doses evenly throughout the day to maintain consistent relief.
What are the common side effects of ibuprofen 400mg tablets?
The most common side effects include nausea, indigestion, stomach pain, and diarrhoea — these are more likely if you take ibuprofen on an empty stomach. Taking the tablet with food or milk usually helps reduce these effects. If you experience severe stomach pain, black stools, or vomiting blood, stop taking ibuprofen and seek medical attention immediately.
How do I manage side effects of ibuprofen 400mg?
Always take ibuprofen with food or milk to minimise stomach irritation, and drink plenty of water with each dose. If indigestion is a persistent problem, your pharmacist may suggest taking a stomach-protecting medicine alongside it. Never exceed the recommended dose, as higher doses significantly increase the risk of gastrointestinal side effects.
Who should not take ibuprofen 400mg tablets?
Ibuprofen is not suitable for people with a history of peptic ulcers, severe kidney or liver disease, severe heart failure, or those with a known allergy to ibuprofen or other NSAIDs such as aspirin. It should also be avoided by pregnant women from 20 weeks onwards and is not licensed for children under 12 at this 400mg strength. Always check with your pharmacist if you are unsure.
Can I take ibuprofen 400mg with paracetamol at the same time?
Yes, ibuprofen and paracetamol can generally be taken together because they work through different mechanisms and do not interact with each other. This combination is sometimes recommended by healthcare professionals for more effective pain control. Always follow the recommended dose for each medicine separately and do not exceed the stated maximum for either.
Can I take ibuprofen 400mg if I have asthma?
Some people with asthma find that ibuprofen and other NSAIDs can trigger or worsen their symptoms — this is known as NSAID-exacerbated respiratory disease. If you have asthma, speak to your GP or pharmacist before taking ibuprofen for the first time. If you have previously tolerated ibuprofen without breathing problems, it is generally considered lower risk, but caution is still advised.
What happens if I miss a dose of ibuprofen 400mg?
If you miss a dose, simply take the next one when it is due — provided at least four to six hours have passed since your last tablet. Do not double up to make up for a missed dose. Ibuprofen is typically taken as needed for pain or fever rather than on a strict schedule, so missing a dose is rarely a concern.
What are the alternatives to ibuprofen 400mg tablets?
Common alternatives include paracetamol (which lacks anti-inflammatory action but is gentler on the stomach), aspirin (another NSAID, not suitable for under-16s), and naproxen (a longer-acting NSAID available on prescription or OTC at lower doses). The right choice depends on your specific condition, medical history, and any other medicines you take — your pharmacist can advise. You can also explore our first aid collection for complementary products.
How long can you take ibuprofen 400mg tablets for?
For self-treatment, ibuprofen should not be taken for more than three consecutive days to reduce a fever, or more than ten days for pain relief, without consulting a doctor or pharmacist. Long-term use increases the risk of gastrointestinal, cardiovascular, and renal side effects. If you need pain relief for longer than this, speak to your GP about a more suitable management plan.
Is ibuprofen 400mg safe to take during pregnancy?
Ibuprofen is not recommended during pregnancy, particularly from 20 weeks onwards, as it may harm the developing baby — including effects on kidney development and amniotic fluid levels. In the third trimester (from 28 weeks), it is contraindicated. If you are pregnant and need pain relief, paracetamol is generally considered the safer option, but always consult your midwife or GP first.
What are the latest studies on ibuprofen and cardiovascular risk?
Regulatory bodies including the MHRA have confirmed that all NSAIDs, including ibuprofen, carry a small increased risk of heart attack and stroke, particularly at high doses or with prolonged use. This risk is considered low for short-term use at the lowest effective dose in otherwise healthy adults. People with existing cardiovascular disease should discuss the risks with their GP before using ibuprofen regularly.
Description
What Are Ibuprofen 400mg Tablets Used For?
If you're dealing with a nagging headache, aching muscles, or the kind of back pain that makes it hard to get through the day, ibuprofen 400mg tablets are one of the most widely used over-the-counter options available in the UK. Ibuprofen Numark 24 x 400mg Tablets offer a reliable, clinically established way to manage mild to moderate pain, reduce inflammation, and bring down a high temperature — all in one convenient pack. At just £5.19 for 24 tablets, it's an accessible choice for everyday pain relief.
Ibuprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It's been used safely for decades and is recommended by the NHS for a wide range of common conditions. Whether you're browsing our pain relief collection for something to keep in the medicine cabinet or you need relief right now, this product is worth knowing about.
How Do Ibuprofen 400mg Tablets Work in the Body?
Ibuprofen works by inhibiting cyclo-oxygenase (COX) enzymes — specifically COX-1 and COX-2. These enzymes drive the production of prostaglandins, which are chemical messengers that trigger pain, swelling, and fever. By blocking them, ibuprofen reduces the inflammatory response at the source rather than simply masking discomfort.
- Inhibits COX-1 and COX-2 enzymes throughout the body
- Reduces prostaglandin synthesis, lowering pain signals
- Decreases local inflammation and swelling in affected tissues
- Acts on the hypothalamus to help normalise elevated body temperature
The onset of action is typically within 20 to 30 minutes of taking a dose orally, with peak plasma concentrations reached within one to two hours. This makes it a practical option when you need relief that works relatively quickly.
Who Is Suitable for Ibuprofen Numark 400mg Tablets?
These tablets are suitable for adults and young people aged 12 and over who need short-term relief from mild to moderate pain or fever. They're particularly useful for:
- Headaches and migraines
- Dental pain and toothache
- Muscular aches, back pain, and joint pain
- Period pain (dysmenorrhoea)
- Fever and symptoms associated with colds and flu
- Minor sports injuries and sprains
They are not suitable for children under 12, pregnant women (especially from 20 weeks onwards), or anyone with a known allergy to ibuprofen or other NSAIDs. If you have a history of stomach ulcers, kidney problems, or cardiovascular disease, speak to your pharmacist or GP before use.
How Do Ibuprofen 400mg Tablets Compare to Alternatives?
| Feature | Ibuprofen Numark 400mg | Paracetamol 500mg |
|---|---|---|
| Active ingredient | Ibuprofen (NSAID) | Paracetamol (analgesic/antipyretic) |
| Anti-inflammatory action | Yes | No |
| Suitable for stomach-sensitive patients | Take with food; caution advised | Generally better tolerated |
| Suitable from age | 12 years and over (400mg strength) | 2 months and over (age-appropriate dose) |
How Should You Store Ibuprofen Numark 400mg Tablets?
Store your ibuprofen 400mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original packaging and out of reach of children at all times. Do not use the tablets after the expiry date printed on the pack — if in doubt, return them to your local pharmacy for safe disposal.
If you're managing multiple health conditions and looking for complementary products, you might also find our vitamins and supplements collection useful for supporting overall wellbeing alongside your pain management routine.
This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.
Ibuprofen Numark 24 x 400mg Tablets specifications
| Treatment category | Pain relief, anti-inflammatory, antipyretic |
| Mechanism of action | COX-1 and COX-2 enzyme inhibition |
| Effective for | Mild to moderate pain, inflammation, fever |
| Suitable for | Adults and young people aged 12 and over |
| Active ingredient | Ibuprofen 400mg |
| Pack size | 24 tablets |
| Strength | 400mg |
| UK classification | Pharmacy (P) medicine |
| Drug class | Non-steroidal anti-inflammatory drug (NSAID) |
| Preparation | Film-coated tablet |
| Route of administration | Oral |
Specifications of Ibuprofen Numark 24 x 400mg Tablets
What Is Ibuprofen Numark 400mg and What Is It Used For?
Ibuprofen Numark 400mg Tablets contain ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain, reduce inflammation, and lower fever. It is indicated for adults and young people aged 12 and over. Common uses include headaches, dental pain, period pain, muscular aches, back pain, and the symptoms of colds and flu. The NHS lists ibuprofen as one of the standard first-line options for short-term pain management in adults.
What Do You Need to Know Before Using Ibuprofen Numark 400mg?
Before taking these tablets, it's important to check whether they are appropriate for you. Do not take ibuprofen if any of the following apply:
- You are allergic to ibuprofen, aspirin, or any other NSAID
- You have or have had a peptic ulcer or gastrointestinal bleeding
- You have severe heart failure, severe kidney disease, or severe liver disease
- You are in the third trimester of pregnancy (28 weeks or more)
- You are under 12 years of age
- You have been told to avoid NSAIDs by your doctor
Use with caution if you have asthma, high blood pressure, a history of heart disease, or mild to moderate kidney or liver impairment. Ibuprofen may interact with the following medicines — always tell your pharmacist what you are taking:
- Aspirin and other NSAIDs (increased risk of side effects)
- Warfarin and other anticoagulants (increased bleeding risk)
- Lithium (ibuprofen can raise lithium blood levels)
- Methotrexate (risk of toxicity increased)
- Antihypertensives including ACE inhibitors and diuretics (reduced effectiveness)
- SSRIs (increased risk of gastrointestinal bleeding)
How Should You Use Ibuprofen Numark 400mg Tablets?
Always take ibuprofen exactly as directed on the label or as advised by your pharmacist. Taking it with food or milk helps protect the stomach lining and reduces the risk of indigestion.
- Take one 400mg tablet with or after food
- Swallow the tablet whole with a full glass of water
- Wait at least four to six hours before taking another dose
- Do not take more than three tablets (1,200mg) in any 24-hour period
- Do not use for more than three days for fever or ten days for pain without medical advice
| Indication | Age Group | Dose | Frequency |
|---|---|---|---|
| Pain / Inflammation | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
| Fever | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
| Period pain | Adults & 12+ years | 400mg (1 tablet) | Up to 3 times daily (every 4–6 hours) |
If you're also managing digestive discomfort alongside pain, you may find our indigestion collection helpful for supporting stomach comfort while taking NSAIDs.
What Are the Possible Side Effects of Ibuprofen Numark 400mg?
Like all medicines, ibuprofen can cause side effects, although not everyone experiences them. Knowing what to look out for helps you use this medicine safely.
Common side effects (may affect up to 1 in 10 people):
- Nausea and vomiting
- Indigestion and heartburn
- Stomach pain or discomfort
- Diarrhoea or constipation
- Headache
Less common side effects (may affect up to 1 in 100 people):
- Dizziness or drowsiness
- Fluid retention (oedema)
- Raised blood pressure
- Skin rash or itching
- Worsening of asthma symptoms
Seek immediate medical attention if you experience signs of a serious allergic reaction (swelling of the face, lips, or throat, difficulty breathing), black or bloody stools, or severe stomach pain. These may indicate a rare but serious reaction requiring urgent care. If you're also managing cold or flu symptoms alongside pain, our cold and flu collection has additional products that may help.
How Should You Store Ibuprofen Numark 400mg Tablets?
- Store below 25°C in a dry place away from direct heat and sunlight
- Keep in the original blister packaging until use
- Keep out of the sight and reach of children
- Do not use after the expiry date printed on the pack
- Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy
References
- https://www.nhs.uk/medicines/ibuprofen-for-adults/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/who-can-and-cannot-take-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/side-effects-of-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/how-and-when-to-take-ibuprofen/
- https://www.nhs.uk/medicines/ibuprofen-for-adults/taking-ibuprofen-with-other-medicines-and-herbal-supplements/
- https://bnf.nice.org.uk/drugs/ibuprofen/
Written and reviewed by our qualified team
Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.
Frequently Asked Questions
Where can I buy ibuprofen 400mg tablets online in the UK?
You can buy Ibuprofen Numark 24 x 400mg Tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply add the product to your basket and complete your order for convenient home delivery. Browse our full pain relief collection for more options.
How does ibuprofen 400mg work in the body?
Ibuprofen works by blocking COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins — the chemicals that cause pain, swelling, and fever. By reducing prostaglandin levels, ibuprofen tackles the underlying inflammatory process rather than just dulling the sensation of pain. This is why it's particularly effective for conditions involving inflammation, such as sprains or period pain.
How do I take ibuprofen 400mg tablets step by step?
Take one 400mg tablet with or after food, swallowed whole with a full glass of water. Wait at least four to six hours before taking another dose, and do not exceed three tablets in any 24-hour period. If your symptoms persist beyond three days (fever) or ten days (pain), consult your pharmacist or GP.
What is the correct dose of ibuprofen 400mg for adults?
The standard adult dose is one 400mg tablet taken up to three times daily, with at least four to six hours between each dose. The maximum daily dose for self-treatment is 1,200mg (three tablets) in 24 hours. Higher doses are sometimes prescribed by doctors but should not be taken without medical supervision.
When is the best time to take ibuprofen 400mg tablets?
There is no single "best" time of day — the most important thing is to take ibuprofen with or after food to protect your stomach lining. If you're taking it for period pain, starting at the first sign of discomfort (rather than waiting for pain to peak) tends to give better results. Space your doses evenly throughout the day to maintain consistent relief.
What are the common side effects of ibuprofen 400mg tablets?
The most common side effects include nausea, indigestion, stomach pain, and diarrhoea — these are more likely if you take ibuprofen on an empty stomach. Taking the tablet with food or milk usually helps reduce these effects. If you experience severe stomach pain, black stools, or vomiting blood, stop taking ibuprofen and seek medical attention immediately.
How do I manage side effects of ibuprofen 400mg?
Always take ibuprofen with food or milk to minimise stomach irritation, and drink plenty of water with each dose. If indigestion is a persistent problem, your pharmacist may suggest taking a stomach-protecting medicine alongside it. Never exceed the recommended dose, as higher doses significantly increase the risk of gastrointestinal side effects.
Who should not take ibuprofen 400mg tablets?
Ibuprofen is not suitable for people with a history of peptic ulcers, severe kidney or liver disease, severe heart failure, or those with a known allergy to ibuprofen or other NSAIDs such as aspirin. It should also be avoided by pregnant women from 20 weeks onwards and is not licensed for children under 12 at this 400mg strength. Always check with your pharmacist if you are unsure.
Can I take ibuprofen 400mg with paracetamol at the same time?
Yes, ibuprofen and paracetamol can generally be taken together because they work through different mechanisms and do not interact with each other. This combination is sometimes recommended by healthcare professionals for more effective pain control. Always follow the recommended dose for each medicine separately and do not exceed the stated maximum for either.
Can I take ibuprofen 400mg if I have asthma?
Some people with asthma find that ibuprofen and other NSAIDs can trigger or worsen their symptoms — this is known as NSAID-exacerbated respiratory disease. If you have asthma, speak to your GP or pharmacist before taking ibuprofen for the first time. If you have previously tolerated ibuprofen without breathing problems, it is generally considered lower risk, but caution is still advised.
What happens if I miss a dose of ibuprofen 400mg?
If you miss a dose, simply take the next one when it is due — provided at least four to six hours have passed since your last tablet. Do not double up to make up for a missed dose. Ibuprofen is typically taken as needed for pain or fever rather than on a strict schedule, so missing a dose is rarely a concern.
What are the alternatives to ibuprofen 400mg tablets?
Common alternatives include paracetamol (which lacks anti-inflammatory action but is gentler on the stomach), aspirin (another NSAID, not suitable for under-16s), and naproxen (a longer-acting NSAID available on prescription or OTC at lower doses). The right choice depends on your specific condition, medical history, and any other medicines you take — your pharmacist can advise. You can also explore our first aid collection for complementary products.
How long can you take ibuprofen 400mg tablets for?
For self-treatment, ibuprofen should not be taken for more than three consecutive days to reduce a fever, or more than ten days for pain relief, without consulting a doctor or pharmacist. Long-term use increases the risk of gastrointestinal, cardiovascular, and renal side effects. If you need pain relief for longer than this, speak to your GP about a more suitable management plan.
Is ibuprofen 400mg safe to take during pregnancy?
Ibuprofen is not recommended during pregnancy, particularly from 20 weeks onwards, as it may harm the developing baby — including effects on kidney development and amniotic fluid levels. In the third trimester (from 28 weeks), it is contraindicated. If you are pregnant and need pain relief, paracetamol is generally considered the safer option, but always consult your midwife or GP first.
What are the latest studies on ibuprofen and cardiovascular risk?
Regulatory bodies including the MHRA have confirmed that all NSAIDs, including ibuprofen, carry a small increased risk of heart attack and stroke, particularly at high doses or with prolonged use. This risk is considered low for short-term use at the lowest effective dose in otherwise healthy adults. People with existing cardiovascular disease should discuss the risks with their GP before using ibuprofen regularly.
