ColdZyme Mouth & Throat Spray Spray 20ml

What Is ColdZyme Mouth Spray and How Can It Help?

Nobody enjoys the misery of a blocked nose, sore throat, and that general feeling of being run down. The common cold is one of the most frequent illnesses in the UK, with adults catching an average of two to four colds per year according to the NHS. ColdZyme mouth spray is a medical device — not a medicine — designed to help reduce both the risk of catching a cold and the duration of symptoms once they start. At just £13.18 for a 20ml bottle, it offers a convenient, easy-to-use option you can keep in your bag or desk drawer. If you're looking for other products to support your health during cold season, browse our Cold and Flu collection for a wider range of options.

ColdZyme is classified as a Class IIa medical device in the EU and UK. It contains a trypsin-based formulation derived from cod, combined with glycerol and other excipients. Because it works as a physical barrier rather than a pharmacological agent, it does not interact with most medicines in the way a conventional drug might.

How Does ColdZyme Mouth & Throat Spray Work?

The mechanism behind ColdZyme is straightforward but clever. When you spray it to the back of your throat, it forms a thin protective layer over the mucous membrane. This barrier is thought to reduce the ability of cold viruses — primarily rhinoviruses — to attach to and infect the cells lining your throat.

• The trypsin enzyme in the formulation may help to break down viral proteins on contact.
• Glycerol helps the spray adhere to the mucosal surface, prolonging the protective effect.
• The barrier reduces viral load in the throat, which may shorten the duration of illness.
• It works locally in the throat rather than being absorbed systemically.

A published randomised controlled trial found that ColdZyme significantly reduced the duration of the common cold compared to placebo. While the evidence base is still growing, the product has been available in Scandinavia for over a decade and has a well-established safety profile.

Who Should Consider Using ColdZyme Throat Spray?

ColdZyme is suitable for a wide range of people who want to take a proactive approach to cold prevention or early symptom management. It is particularly useful if you work in a busy environment, travel frequently, or have regular contact with young children — all situations where cold virus exposure is higher.

• Adults who want to reduce the risk of catching a cold during high-exposure periods.
• People who feel the first signs of a sore throat or cold coming on.
• Children aged 4 years and over (under adult supervision).
• Those who prefer a non-pharmacological approach to cold management.

It is not suitable for anyone with a known allergy to fish or cod, as the trypsin enzyme is derived from cod. Always read the label carefully before use.

How Does ColdZyme Compare to Other Cold Throat Sprays?

Is ColdZyme Suitable for Everyday Use and How Should It Be Stored?

The ColdZyme mouth spray should be stored below 25°C and must not be frozen. Once opened, it should be used within three months. Keep the cap on when not in use to maintain hygiene and product integrity. It does not require refrigeration, making it easy to carry with you day to day.

If you are pregnant, breastfeeding, or have an underlying health condition, it is always worth checking with your pharmacist before starting any new product — even a medical device. You might also find it helpful to explore our Vitamins and Supplements collection for immune-support options to use alongside ColdZyme during winter months.

This product is a medical device. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

What Is ColdZyme Mouth & Throat Spray and What Is It Used For?

ColdZyme Mouth & Throat Spray 20ml is a Class IIa medical device used to help reduce the risk of catching the common cold and to shorten the duration of cold symptoms. It is applied directly to the back of the throat, where it forms a protective barrier against cold viruses. The NHS notes that the common cold is caused primarily by rhinoviruses and spreads easily through respiratory droplets and hand-to-face contact. ColdZyme offers a non-pharmacological way to help protect the throat during periods of high viral exposure — for example, during winter months or when you are around people who are already unwell.

It is not a treatment for influenza, COVID-19, or bacterial throat infections. If your symptoms are severe, persistent, or accompanied by a high fever, you should seek advice from your GP or call NHS 111.

What Do You Need to Know Before Using ColdZyme Spray?

Before using ColdZyme, it is important to check whether it is appropriate for you. Although it is a medical device rather than a medicine, there are still important contraindications and precautions to be aware of.

Do not use ColdZyme if:

• You have a known allergy to fish or cod — the trypsin enzyme is derived from cod.
• You are allergic to any other ingredient listed on the label (including glycerol or ethanol).
• The child is under 4 years of age.

Take care and speak to a pharmacist if:

• You are pregnant or breastfeeding.
• You have a known immune deficiency or are taking immunosuppressant medicines.
• You have a history of severe allergic reactions (anaphylaxis).

Drug interactions:

• No clinically significant drug interactions have been identified for ColdZyme.
• As a medical device acting locally in the throat, it is not absorbed systemically and is unlikely to interact with oral medicines.
• If you are taking any prescribed medicines, check with your pharmacist if you are unsure.

How Should You Use ColdZyme Mouth & Throat Spray?

Using ColdZyme correctly is key to getting the most benefit from it. The spray should be directed to the back of the throat — not just the front of the mouth — to ensure the protective barrier forms where cold viruses are most likely to enter. For broader throat and ear, nose, and throat health support, explore our dedicated collection.

1. Shake the bottle gently before each use.
2. Remove the cap and hold the bottle upright.
3. Point the nozzle towards the back of your throat.
4. Press the pump twice to release two sprays.
5. Swallow normally after spraying — do not rinse your mouth immediately afterwards.
6. Replace the cap after use.

What Are the Possible Side Effects of ColdZyme Spray?

ColdZyme is generally well tolerated. Because it acts locally in the throat and is not absorbed into the bloodstream, systemic side effects are not expected. However, as with any product applied to a mucous membrane, some people may notice mild local effects.

Common side effects:

• Mild throat irritation or a slight burning sensation immediately after spraying.
• Temporary change in taste.

Less common side effects:

• Mild nausea if a large amount is swallowed.
• Localised dryness in the throat.

If you experience signs of an allergic reaction — such as swelling of the mouth or throat, difficulty breathing, or a skin rash — stop using ColdZyme immediately and seek urgent medical attention. Allergic reactions to cod-derived ingredients, while uncommon, can be serious in susceptible individuals.

How Should You Store ColdZyme Mouth & Throat Spray?

Correct storage helps maintain the integrity of the formulation and ensures the product remains effective throughout its shelf life. You may also want to consider storing complementary products such as pain relief options alongside ColdZyme in your home medicine cabinet for cold season.

• Store below 25°C.
• Do not freeze.
• Keep the bottle upright with the cap firmly in place when not in use.
• Once opened, use within 3 months.
• Keep out of the reach and sight of children.
• Do not use after the expiry date printed on the label.
• Do not store in direct sunlight or near a heat source.