Clotrimazole and Fluconazole Thrush Treatment Bundle - 3 Pack

What Is the Thrush Treatment Bundle and How Does It Help?

Vaginal thrush is one of the most common fungal infections in women, caused by an overgrowth of the yeast Candida albicans. It can cause itching, soreness, a thick white discharge, and general discomfort around the vagina and vulva. The good news? It is very treatable. The thrush treatment bundle from Cured Pharmacy combines two well-established antifungal medicines — clotrimazole cream and a fluconazole 150mg capsule — into one convenient 3 pack, giving you everything you need to tackle both the internal infection and the external symptoms at the same time. If you are looking for a broader range of antifungal options, you can also browse our athletes foot and fungal infections collection.

Each pack contains a single-dose fluconazole 150mg capsule alongside clotrimazole 2% cream, designed to work together for a more complete approach to thrush relief. Having three packs means you are prepared for future episodes without needing to reorder urgently — a practical choice for anyone who experiences thrush more than once a year.

How Does the Clotrimazole and Fluconazole Bundle Work?

Both medicines in this bundle are antifungals, but they work in different ways and target different aspects of the infection.

• Fluconazole (oral capsule): Works systemically by inhibiting the fungal enzyme lanosterol 14-alpha-demethylase. This disrupts the production of ergosterol, a key component of the Candida cell membrane, causing the fungal cells to die.
• Clotrimazole (topical cream): Applied directly to the external vulval area, it also targets ergosterol synthesis but acts locally to relieve itching, soreness, and redness on the skin surface.
• Combined effect: The oral capsule addresses the internal yeast overgrowth while the cream soothes external irritation — a dual approach that many women find more effective than using either treatment alone.

Who Should Use the Clotrimazole and Fluconazole Bundle?

This bundle is suitable for women who have previously been diagnosed with vaginal thrush by a doctor and recognise the same symptoms returning. It is an over-the-counter (OTC) product, meaning no prescription is needed, but it is not appropriate for everyone.

It is suitable for:

• Women aged 16 to 60 with symptoms of vaginal thrush
• Those who have had thrush before and recognise the symptoms
• Women who want to treat both internal and external symptoms simultaneously
• Anyone who prefers to keep a supply at home for future episodes

How Does This Bundle Compare to Using a Single Thrush Treatment?

Is the Thrush Treatment Bundle Stored Correctly at Home?

Storing your medicines correctly matters more than people often realise. Both the fluconazole capsule and the clotrimazole cream in this thrush treatment bundle should be kept below 25°C, in a dry place away from direct sunlight. Do not store them in the bathroom, where heat and humidity can affect the integrity of the medicines. Keep them out of reach of children at all times.

If you are managing other aspects of your health alongside thrush, our women's health collection includes a range of products that may be relevant to you.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

What Is the Clotrimazole and Fluconazole Bundle and What Is It Used For?

This bundle is an OTC antifungal treatment used to relieve the symptoms of vaginal thrush in women aged 16 to 60. Vaginal thrush is caused by an overgrowth of Candida albicans, a yeast that naturally lives in the body but can multiply when conditions change — for example, after a course of antibiotics, during hormonal changes, or when the immune system is under pressure. Symptoms typically include itching, soreness, redness around the vagina and vulva, and a thick, white, odourless discharge.

The bundle contains two complementary treatments: a fluconazole 150mg capsule taken by mouth to address the internal infection, and a clotrimazole 2% cream applied externally to soothe irritated skin. Together, they form a complete approach to managing a thrush episode.

What Do You Need to Know Before Using the Clotrimazole and Fluconazole Bundle?

Do not use this bundle if any of the following apply to you:

• You are under 16 or over 60 years of age
• You are pregnant, trying to become pregnant, or breastfeeding
• You have had thrush more than twice in the last six months
• You have never been diagnosed with thrush before
• You have abnormal or irregular vaginal bleeding
• You have sores, ulcers, or blisters on or around the vagina
• You have a known allergy to fluconazole, clotrimazole, or any azole antifungal
• You have liver or kidney problems
• You have a weakened immune system (e.g. HIV, diabetes, or are taking immunosuppressants)

Fluconazole can interact with a number of medicines. Tell your pharmacist if you are taking any of the following:

• Warfarin or other anticoagulants — fluconazole can increase bleeding risk
• Certain statins (e.g. simvastatin) — increased risk of muscle problems
• Rifampicin — may reduce the effectiveness of fluconazole
• Phenytoin or other antiepileptics
• Ciclosporin or tacrolimus (immunosuppressants)
• Some antidiabetic medicines (e.g. glibenclamide)

How Should You Use the Clotrimazole and Fluconazole Bundle?

1. Take one fluconazole 150mg capsule by mouth with a glass of water. This is a single dose — do not take more than one capsule per episode.
2. Wash your hands thoroughly before and after applying the clotrimazole cream.
3. Apply a small amount of clotrimazole 2% cream to the affected external area (vulva and surrounding skin).
4. Gently rub in the cream two to three times daily.
5. Continue applying the cream until external symptoms have fully resolved, even if the internal symptoms improve quickly.
6. Avoid getting the cream in your eyes. If contact occurs, rinse thoroughly with water.

For more information on related treatments, you can explore our thrush treatments collection.

What Are the Possible Side Effects of the Clotrimazole and Fluconazole Bundle?

Like all medicines, this bundle can cause side effects, although not everyone experiences them. Most side effects are mild and resolve on their own.

Common side effects (fluconazole):

• Nausea or stomach discomfort
• Headache
• Dizziness
• Diarrhoea

Common side effects (clotrimazole cream):

• Mild burning or stinging at the application site
• Skin redness or irritation

Less common side effects:

• Skin rash or hives
• Abdominal pain
• Elevated liver enzymes (rare, with fluconazole)
• Severe allergic reaction (anaphylaxis) — seek emergency help immediately if you experience swelling of the face, lips, or throat, or difficulty breathing

How Should You Store the Clotrimazole and Fluconazole Bundle?

• Store below 25°C in a cool, dry place
• Keep away from direct sunlight and sources of heat
• Do not store in the bathroom or near a sink
• Keep out of the sight and reach of children
• Do not use after the expiry date printed on the packaging
• Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you are also managing other intimate health concerns, our condoms and sexual health collection may be useful.